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The Benefits of Ellagic Acid

 

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Ellagic Acid

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Pomegranate, walnuts and red raspberries are examples of rich dietary sources of ellagic acid and the precursors to ellagic acid called ellagitannins. Some dietary ellagic acid is converted in your intestines into compounds called urolithins, which are also absorbed and may be responsible for some of the health benefits of ellagic acid. Ellagic acid and its metabolic products appear to have anti-cancer properties, especially against prostate cancer.

Sources and Metabolism

Ellagic acid is a small phytochemical that can occur naturally in foods, and it also can be produced as a breakdown product of larger phytochemicals called ellagitannins in your intestines. Many plant foods contain some ellagic acid. In addition to pomegranate, foods with relatively high levels include strawberries, blackberries, raspberries, cranberries, walnuts and pecans. Absorption of ellagic acid from food occurs quite rapidly, with maximum levels in your blood after about one hour, after which blood levels decline as ellagic acid is metabolized to other compounds.


Prostate Cancer

Ellagic acid metabolic products are found concentrated in prostate tissues of male mice fed pomegranate ellagitannins. In human subjects with prostate cancer or enlargement who were provided walnuts or pomegranate juice for the three days just prior to surgery, metabolic products of ellagic acid were found to be concentrated in prostate tissue, according to a study published in the March 2010 issue of “Molecular Nutrition and Food Research.” A study presented in the July 1, 2006, issue of “Clinical Cancer Research” reported a reduction in prostate cancer disease progression following surgery in patients given 8 ounces of pomegranate juice per day.


Obesity and Inflammation

Obesity is a condition of overweight that involves inflammation in your fatty tissues. Ellagic acid was found to lower fatty tissue levels of an inflammatory compound called resistin in mice, according to a study in the Jan. 13, 2012, issue of "Biochemical and Biophysical Research Communications." High blood levels of resistin in people are associated with diabetes and coronary artery disease and can be caused by white blood cell infiltration of fatty tissues. Although ellagic acid has not been shown to inhibit resistin production in people, pre-clinical work suggests a possible anti-inflammatory effect in obesity-related diseases.


Glucose Metabolism

Ellagitannins from strawberries were found to be inhibitors of pancreatic amylase, which slows initial steps of starch digestion, as reported in the Oct. 2010 issue of the “Journal of Medicinal Food.” The final step in starch digestion to glucose for absorption is facilitated by an intestinal enzyme called alpha-glucosidase. Ellagic acid is an inhibitor of alpha-glucosidase. Thus, ellagitannins and ellagic acid may decrease the rate of glucose entry into the bloodstream following a meal. Most ellagic acid in strawberries and raspberries is found in the seeds and pulp, with much lower amounts in the juices.

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