Environmental toxins is one of the 9 variables in your health and
longevity we assess. The other 8 variables are genetic variants,
trauma, what you eat, what you drink, how you rest, how you
exercise, what/how you braethe, and what you think. Environmental
toxins are a real threat to our health and so often overlooked by
most doctors as a potential causation for the symptoms the patient
are presenting with.
Some 80, 000 chemicals have been introduced into our environment
since WWII. The vast majority of these chemicals are not even
monitored by the EPA (Environmenatl Protection Agency). The source
of these toxins is through the food chain from the food we eat, the
water we drink, and the air we breathe. ADHD, autism, cardiovascular
disease, diabetes, auto-immune disease, hypothyroidism, and sex
hormone imbalances/deficiencies have all been linked to
environmental toxins.
An approach that evaluates the body burden of potential
environmental toxins coupled with supplementing essential
micronutrients that chelate specific toxins and detoxify them from
the body and eliminating the source of these pollutants with air and
wate purification systems and consuming organic foods produces
positive changes in the health of individuals suffering from
environmental toxins.
The following are excerpts from Is Your Environment Stressing You
Out? How To Pro-Actively Protect Yourself From Environmental Toxins
by Kely Miller DC NMD FASA FBAARM CFMP.
The concept I would like you to grasp here is that for many of us
our environment is causing a never ending fight/flight response for
many. As these stressors accumulate through the aging process we
lose the ability to maintain homeostasis. It is no wonder so many
are so sick. Specifically, the water we are drinking, showering in,
and bathing and swimming in, the air we are breathing at home and/or
work, and much of the food we are eating is full of toxins that are
relentlessly attacking us and breaking down our immune and
detoxification systems. This prolonged fight/flight response leads
to inflammation with subsequent hormone depletion, micronutrient
depletion, sticky blood, endothelial vascular damage, small
intestine hyperpermeability (leaky gut), and mitochondrial
dysfunction. We need to eliminate or at least greatly reduce the
body burden of heavy metals, pesticides, herbicides, petroleum
byproducts, PBAs, PCBs, and the like in order to get healthier.
This book is the third in a seven book series called Health
Restoration. This book reveals potential causes for chronic illness
and diseases that most individuals and doctors have not considered.
For example, mercury toxicity can cause two common health problems –
hypertension and hypothyroidism. Assessing the hypertensive or
hypothyroid patient for mercury toxicity is not even in the thought
process of most physicians…………..
Is your food making you sick? Do you suffer from chronic fatigue,
fibromyalgia, migraines, irritable bowel syndrome, heartburn/GERD,
chronic sinusitis, fibromyalgia, arthritis, chronic joint pain,
chronic sinus problems, insomnia, weight imbalances, autism/ADD,
chronic diarrhea, skin eruptions, muscle pain?
Are you suffering from a stubborn health problem that won’t go away
no matter what you do? Or perhaps the medications or treatments
you’re taking aren’t actually getting at the root cause of your
illness- but you want something that will? If you feel this way, or
know someone that does, consider some important facts:
Medical Research has shown that sensitivities to foods and
food-chemicals can be involved in a wide variety of painful symptoms
and chronic health problems.
If foods and additives in your diet are causing your illness,
whatever medications you are taking will ultimately fail because
they only mask the symptoms. They don’t treat the underlying cause
of the symptoms. And as it is too often the case, many medications
have side effects that can lead to other health problems.
If food sensitivities are causing your illness and you don’t
properly address them, you could easily end up suffering for many
years, spending thousands of dollars and lost time, productivity,
and quality of life for treatments that will never work the way you
want.
The solution for illness caused by food sensitivity…..
With the patented blood test called MRT (Mediator Release Test) you
can account for both Type 3 and Type 4 pathways. MRT also identifies
reactions to food chemicals. This is translated into faster and more
complete relief for those who test with MRT. In fact, independent
studies confirm MRT is the most accurate and most comprehensive
blood test available for food and food-chemical reactions.
A simple blood test could hold the answer to your chronic health
problems. Call today for a consultation at our Temple Terrace,
Florida office.
Heavy Metal Testing
Heavy metal poisoning from cadmium, lead, arsenic, aluminum, and
others, especially mercury may be more prevalent than anyone
suspected. To my knowledge there have not been multiple studies on a
general population to determine if heavy metal toxicities exist in a
large percentage of the population. However, in 2007, one thousand
people gathered for a four day health seminar related to mercury
testing. Of the one thousand attendees, 680 men and women from the
ages of eighteen to seventy who lived throughout the U. S. and
Canada were tested. An alarming ninety five percent of the people
tested with body mercury levels in the ‘Elevated’ or ‘Very Elevated’
reference range, and just five percent tested in the ‘Green’, or 0
reference range.
Removing Heavy Metals
Cadmium and lead can be found in automobile and industrial vapors,
and lead may come from our fillings, and lead contamination can
occur from lead-based paints. Aluminum toxicity can occur secondary
to exposure to aluminum cookware and cans. Arsenic is frequently
found in well water. Of all these, mercury seems to be most
prevalent. In 1991, the World Health Organization, conformed that,
“Mercury contained in dental amalgam is the greatest source of
mercury vapor in non-idustrialized settings exposing the concerned
population to mercury levels significantly exceeding those set for
food and for air. But “silver” fillings are not the only source of
mercury. Certain types and brands of the following common products
also may contain mercury: fish, thermometers, button cell batteries,
skin crèmes, vaccines, barometers, cosmetics, tattoos, thermostats,
light-up sports shoes, disinfectants, and fluorescent light bulbs.
Exposure to mercury can occur in a number of ways. On may come in
contact with mercury or its fumes from broken thermometer, and other
spills in the home, school, or workplace, or breathe in airborne
mercury from a coal burning power plant, mining operations, or other
industrial sources. Thousands of people work in an occupation that
uses mercury, such as a dental office or manufacturing plant.
Millions are exposed daily by eating fish that have been
contaminated with methyl mercury. In general, the larger the fish,
the more susceptible it is to mercury contamination. Different
regions around the world have different fish on the “consumer
beware” list, but a few of the most at risk are shark, swordfish,
grouper, tuna, Chilean Sea Bass, marlin, tilefish, and farmed
salmon. (Do not eat farmed salmon because of the extreme high levels
of arachadonic acid, which causes inflammation.)
There are a number of chelating agents out there to determine heavy
metal toxicity, two of which are DMPS and DMSA. For mercury,
cadmium, and lead, we like DMPS because approximately fifty percent
of oral administered DMPS is rapidly absorbed in the
gastrointestinal tract and is excreted by the kidneys. The highest
urinary concentration occurs two to three hours after oral
administration. Neither DPMS nor its metabolites are detected twelve
hours after administration in animal studies. DMPS is the most
productive agent for the provoked urine toxic element, particularly
when mercury is of concern. Only about twenty percent of the DMSA is
absorbed into the gastrointestinal tract. Studies performed at
Doctor’s Data Laboratory indicate that oral DMSA (30mg/kg/day) for
one to three days only yields about one-fifth to one-tenth of the
amount of mercury in the urine as a single dose of DMPS. Therefore,
many physicians prefer DMPS instead of DMSA for the initial
challenge and subsequent detoxifying agent for mercury. For heavy
metals other than mercury, cadmium, or lead, we prefer liposomal
EDTA for detoxification.
What does mercury do to the body? Mercury is a toxic heavy metal
that is not found naturally in the body. In fact, it is a poison
that can cause long-lasting damage to the body. According to the
World Health Organization.”Recent studies suggest that mercury may
not have a thresh-hold level in which some adverse effects do not
occur.” The following are a few health issues that have been linked
to mercury exposure: Emotions – rage and anger, depression, mood
swings, anxiety. Reproductive System – infertility, impotency, birth
defects. Hormones and Sexuality – low thyroid function, low libido,
erectile dysfunction. Heart – arrhythmia, shortness of breath,
angina, heart failure. Brain – “brain fog”, dementia, Alzheimer’s,
“senior moments”. General Health – fatigue, unexplainable weight
gain, cold extremities, headaches. Immune System – recurring
infection, autoimmune disease, rashes, allergies/asthma. Nervous
System – numbness, tremors, neuropathy, vision/hearing problems, MS
or ALS.
The detoxification length is dependent upon test levels and
individual response to treatment. However, in the outcome of one
group of 147 individuals using DMPS for mercury toxicity, sixty
three percent or ninety three out of one hundred forty four obtained
an elimination average of sixty nine percent in thirty to sixty
days.
GPL-TOX: Toxic Non-Metal Chemical Profile
Every day, we are exposed to hundreds of toxic chemicals through
products like pharmaceuticals, pesticides, packaged foods, household
products, and environmental pollution. As we have become more
exposed to chemical-laden products and to toxic chemicals in food,
air, and water, we have been confronted with an accelerating rate of
chronic illnesses like cancer, heart disease, chronic fatigue
syndrome, chemical sensitivity, autism spectrum disorders, ADD/AD(H)D,
autoimmune disorders, Parkinson’s disease, and Alzheimer’s disease.
Because exposure to environmental pollutants has been linked to many
chronic diseases, The Great Plains Laboratory has created GPL-TOX, a
toxic non-metal chemical profile that screens for the presence of
172 different toxic chemicals including organophosphate pesticides,
phthalates, benzene, xylene, vinyl chloride, pyrethroid
insecticides, acrylamide, perchlorate, diphenyl phosphate, ethylene
oxide, acrylonitrile, and more. This is one of the common panels I
run to evaluate the body burden of environmental toxins. This
profile also includes Tiglylglycine (TG), a marker for mitochondrial
disorders resulting from mutations of mitochondrial DNA. These
mutations can be caused by exposure to toxic chemicals, infections,
inflammation, and nutritional deficiencies.
There are many advantages to using the GP-TOX profile. Some of these
are the following:
GPL-TOX screens for 172 different environmental pollutants using 18
different metabolites, all from a single urine sample.
GPL-TOX uses the power of advanced mass spectrometry (MS/MS), which
is necessary to detect lower levels of certain genetic,
mitochondrial, and toxic chemical markers that conventional mass
spectrometry often misses.
GPL-TOX also includes Tiglylglycine, a marker for mitochondrial
damage, which is often seen in chronic toxic chemical exposure.
GPL-TOX pairs perfectly with their Organic Acids Test (OAT) and
Glyphosate Test in the Enviro-TOX Panel. This panel offers
comprehensive testing to assess exposure to common environmental
toxins and the damage that can be caused by this exposure, all at a
great value, and all from one urine sample.
The following groups of chemicals are testing in the GPL-TOX panel.
Phthalates
Perhaps the most widespread group of toxic chemicals found in our
environment. Phthalates are commonly found in after shave lotions,
aspirin, cosmetics, detergents, foods microwaved with plastic
covers, oral pharmaceutical drugs, intravenous products prepared in
plastic bags, hair sprays, insecticides, insect repellents, nail
polish, nail polish remover, skin care products, adhesives,
explosives, lacquer, janitorial products, perfumes, paper coatings,
printing inks, safety glass, and varnishes. Phthalates have been
implicated in reproductive damage, depressed leukocyte function, and
cancer. Phthalates have also been found to impede blood coagulation,
lower testosterone, and alter sexual development in children. Low
levels of phthalates can feminize the male brain of the fetus, while
high levels can hyper-masculinize the developing male brain.
Vinyl Chloride
Vinyl chloride is an intermediate in the synthesis of several
commercial chemicals, including polyvinyl chloride (PVC). Exposure
to vinyl chloride may cause central nervous system depression,
nausea, headache, dizziness, liver damage, degenerative bone
changes, thrombocytopenia, enlargement of the spleen, and death.
Benzene
Benzene is an organic solvent that is widespread in the environment.
Benzene is a by-product of all sources of combustion, including
cigarette smoke, and is released by outgassing from synthetic
materials, and is a pollutant released by numerous industrial
processes. Benzene is an extremely toxic chemical that is mutagenic
and carcinogenic. High exposures to benzene cause symptoms of
nausea, vomiting, dizziness, lack of coordination, central nervous
system depression, and death. It can also cause hematological
abnormalities.
Pyrethrins
Pyrethrins are widely used as insecticides. Exposure during
pregnancy doubles the likelihood of autism. Pyrethrins may affect
neurological development, disrupt hormones, induce cancer, and
suppress the immune system.
Xylenes
Xylenes (dimethylbenzenes) are solvents found not only in common
products such as paints, lacquers, pesticides, cleaning fluids, fuel
and exhaust fumes, but also in perfumes and insect repellents.
Xylenes are oxidized in the liver and bound to glycine before
eliminated in urine. High xylene levels may be due to the use of
certain perfumes and insect repellents. High exposures to xylene
create an increase in oxidative stress, causing symptoms such as
nausea, vomiting, dizziness, central nervous system depression, and
death. Occupational exposure is often found in pathology
laboratories where xylene is used for tissue processing.
Styrene
Styrene is used in the manufacturing of plastics, in building
materials, and is found in car exhaust fumes. Polystyrene and its
copolymers are widely used as food-packaging materials. The ability
of styrene monomer to leach from polystyrene packaging to food has
been reported. Occupational exposure due to inhalation of large
amounts of styrene adversely impacts the central nervous system,
causes concentration problems, muscle weakness, tiredness and
nausea, and irritates the mucous membranes of the eyes, nose, and
throat.
Organophosphates
Organophosphates are one of the most toxic groups of substances used
throughout the world. They are often used as biochemical weapons and
terrorist agents, but are most commonly used in pesticide
formulations. Organophospates are inhibitors of cholinesterase
enzymes, leading to overstimulation of nerve cells, causing
sweating, salivation, diarrhea, abnormal behavior, including
aggression and depression. Children exposed to organophosphates have
more than twice the risk of developing pervasive developmental
disorder (PDD), an autism spectrum disorder. A study done in the San
Francisco Bay area found that in California agricultural areas,
children born to mothers living within 500 meters of fields where
organochlorine pesticides were used were more than 6 times more
likely to develop autism than children whose mothers did not live
near such fields. ASD risk increased with the poundage of
organochlorines applied and decreased with distance from field
sites. Maternal organophosphate exposure has been associated with
various adverse outcomes including having shorter pregnancies and
children with impaired reflexes.
MTBE and ETBE
MTBE and ETBE are gasoline additives used to improve octane ratings.
Exposure to these compounds is most likely due to groundwater
contamination, and inhalation or skin exposure to gasoline or its
vapors and exhaust fumes. MTBE has been demonstrated to cause
hepatic, kidney, and central nervous system toxicity, peripheral
neurotoxicity, and cancer in animals. Since the metabolites of these
compounds are the same, ETBE may be similarly toxic.
2, 4-Dicholorophenoxyacetic (2,4-D)
A very common herbicide that was a part of Agent Orange, used by the
United States during the Vietnam War to increase visibility for war
planes, by destroying plant undergrowth and crops. It is most
commonly used in agriculture on genetically modified foods, and as a
weed killer for lawns. Exposure to 2, 4-D via skin or oral ingestion
is associated with neuritis, weakness, nausea, abdominal pain,
headache, dizziness, peripheral neuropathy, stupor, seizures, brain
damage, and impaired reflexes. 2, 4-D is a known endocrine
disruptor, and can block hormone distribution and cause glandular
breakdown.
Diphenyl Phosphate
This is a metabolite of the organophosphate flame retardant
triphenyl phosphate (TPHP), which is used in plastics, electronic
equipment, nail polish, and resins. TPHP can cause endocrine
disruption. Studies have also linked TPHP to reproductive and
developmental problems.
Acrylamide
Acrylamide can polymerize to form polyacrylamide. Polyacrylamide is
used in many industrial processes such as plastics, food packaging,
cosmetics, nail polish, dyes, and treatment of drinking water. Food
and cigarette smoke are also two major sources of exposure.
Acrylamide has been found in foods like potato chips, French fries,
and many others such as asparagus, potatoes, legumes, nuts, seeds,
beef, eggs, and fish. Asparagine, which is found in these foods can
produce acrylamide when cooked at high temperature in the presence
of sugars. High levels of acrylamide can elevate a patient’s risk of
cancer. In addition, acrylamide is known to cause neurological
damage.
Perchlorate
This chemical is used in the production of rocket fuel, missiles,
fireworks, flares, explosives, fertilizers, and bleach. Studies show
that perchlorate is often found in water supplies. Many food sources
are also contaminated with perchlorate. Perchlorate can disrupt the
thyroid’s ability to produce hormones. The EPA has also labeled
perchlorate a likely human carcinogen. Patients that are high in
perchlorate can use a reverse osmosis water treatment system to
remove the chemical from their water supply.
1,3 Butadiene
This is a chemical made from the processing of petroleum. It is
often a colorless gas with a mild gasoline-like odor. Most of this
chemical is used in the production of synthetic rubber. 1,3
Butadiene is a known carcinogen and has been linked to increased
risk of cardiovascular disease. Individuals that come into contact
with rubber, such as car tires, could absorb 1,3 Butadiene through
the skin. The increased use of old tires in the production of crumb
rubber playgrounds and athletic fields is quite troubling because
children and athletes may be exposed to toxic chemicals this way.
Propylene Oxide
This chemical is used in the production of plastics and is used as a
fumigant. Propylene oxide is used to make polyester resins for
textile and construction industries. It is also used in the
preparation of lubricants, surfactants, and oil demulsifiers. It has
also been used as a food additive, an herbicide, a microbicide, an
insecticide, a fungicide, and a miticide. Propylene oxide is a
probable human carcinogen.
1-Bromopropane (1-BP)
1-Bromopropane is an organic solvent used for metal cleaning, foam
gluing, and dry cleaning. Studies have shown that 1-BP is a
neurotoxin as well as a reproductive toxin. Research indicates that
exposure to 1-BP can cause sensory and motor deficits. Chronic
exposure can lead to decreased cognitive function and impairment of
the central nervous system. Acute exposure can lead to headaches.
Ethylene Oxide
Ethylene oxide is used in many different industries including
agrochemicals detergents, pharmaceuticals, and personal care
products. Ethylene oxide is also used as a sterilizing agent on
rubber, plastics, and electronics. Chronic exposure to ethylene
oxide has been determined to be mutagenic to humans. Multiple
agencies have reported it as a carcinogen. Studies of people exposed
to ethylene oxide show an increased incidence of breast cancer and
leukemia. Caution is needed with ethylene oxide because it is
odorless at toxic levels.
Acrylonitrile
Acrylonitrile is a colorless liquid with a pungent odor. It is used
in the production of acrylic fibers, resins, and rubber. Use of any
of these products could lead to exposure to acrylonitrile. Smoking
tobacco and cigarettes is another potential exposure. Exposure to
acrylonitrile can lead to headaches, nausea, dizziness, fatigue, and
chest pains. The European Union has classified acrylonitrile as a
carcinogen.
The following are a list of conditions in alphabetic order that I
recommend the GPL-TOX panel for:
The seventh sequela of chronic stress and inflammation is
mitochondrial DNA dysfunction. The GPL-TOX profile tests for
Tiglylglycine (TG), one of the most specific markers for
mitochondrial disorders resulting from mutations of mitochondrial
DNA. These mutations can result from exposure to toxic chemicals,
infections, inflammation, and nutritional deficiencies. Mitochondria
are important in all cells in the body, but are especially important
to organs that utilize large amounts of energy, such as the muscles,
heart, and brain. The mitochondria also have several other important
functions in the cell, including steroid synthesis, calcium
regulation, free radical production, and the induction of apoptosis
or programmed cell death, all of which are involved in the
pathogenesis of numerous disorders. The marker used in the GPL-TOX
profile indicates mitochondrial dysfunction by monitoring a
metabolite that is elevated in mitochondrial deficiency of cofactors
such as NAD+, flavin-containing coenzymes, and Coenzyme Q10.
Disorders associated with mitochondrial dysfunction include autism,
Parkinson’s disease, and cancer.
There are multiple metabolites that are measured that are produced
by a body burden of environmental toxins. Some of these are the
following:
These are metabolites of xylenes, solvents found in paints,
lacquers, cleaning agents, pesticides, and gasoline. Exposure to
xylenes generates methylhippuric acid isomers. Avoid/reduce exposure
to these substances.
N-acetyl phenyl cysteine (NAP)
NAP is a metabolite of benzene. Benzene is a solvent that is
widespread in the environment. It is found in cigarette smoke and
gasoline, and is a byproduct of all types of combustion, including
motor vehicle exhaust. Treatment consists of removing sources of
exposure.
Phenylglyoxylic Acid (PGO)
Exposure to environmental styrene may slightly increase
phenylglyoxylic and mandelic acid. Reduce exposure by eliminating
the use of plastic and styrofoam containers for cooking, reheating,
eating or drinking. Elimination of styrene can be accelerated by
supplementing with glutathione and N-acetyl cysteine (NAC).
2-Hydroxyisobutyric Acid (2HIB)
2-Hydroxyisobutyric acid is formed endogenously as a product of
branched-chain amino acid degradation and ketogenesis. This compound
is also the major metabolite of gasoline octane enhancers such as
MTBE and ETBE. Elevated levels indicate environmental exposure and
very high values have been reported in genetic disorders.
Monoethyl Phthalate (MEP)
MEP from diethyl phthalate is the most abundant phthalate metabolite
found in urine. Diethyl phthalate is used in plastic products.
Elevated values indicate exposure from various possible sources.
Elimination of phthalates may be accelerated by sauna treatment.
Dimethylphosphate (DMP) & Diethylphosphate (DEP)
DMP and DEP are major metabolites of many organophosphate
pesticides. Reduce exposure by eating organic foods and avoiding use
of pesticides in your home or garden. Living near agricultural areas
or golf courses and areas regularly sprayed with pesticides will
increase exposure. Elimination of organophosphates can be
accelerated by sauna treatment.
3-Phenoxybenzoic Acid (3PBA)
3-Phenoxybenzoic acid is a metabolite of pyrethroid insecticides.
Elimination can be accelerated by sauna treatment.
2,4-Dichlorophenoxyacetic Acid (2,4-D)
2,4-D was an ingredient in Agent Orange, and is most commonly used
in agriculture of genetically modified foods, and as a weed killer
for lawns. Reduce exposure by eating organic foods and avoiding use
of pesticides in your home or garden.
Tiglylglycine (TG)
TG is a marker for mitochondrial dysfunction. Mutations of
mitochondria DNA may result from exposure to toxic chemicals,
infections, inflammation, and nutritional deficiencies.
N-acetyl-S-(2-carbamoylethyl)-cysteine
NAE is a metabolite of acrylamide, which is detoxified through a
two-step process. First acrylamide is metabolized by the cytochrome
P450s. Second it is conjugated to glutathione in order to make it
more water soluble. Acrylamide is used in many industrial processes
such as plastics, food packaging, cosmetics, nail polish, dyes, and
treatment of drinking water. High levels of acrylamide can elevate a
patient’s risk of cancer and cause neurological damage.
Supplementation with glutathione can assist in the elimination of
this compound.
Diphenyl Phosphate
This is a metabolite of the organophosphate flame retardant
triphenyl phosphate (TPHP), which is used in plastics, electronic
equipment, nail polish, and resins. TPHP can cause endocrine
disruption. Studies have also linked TPHP to reproductive and
developmental problems.
Perchlorate
Perchlorate is used in the production of rocket fuel, missiles,
fireworks, flares, explosives, fertilizers, and bleach. Studies show
that perchlorate is often found to contaminate water supplies and
food sources. It can disrupt the thyroid’s ability to produce
hormones. The EPA has also labeled perchlorate a likely human
carcinogen. Patients that are high in perchlorate can use a reverse
osmosis water treatment system or the Mutipure Aquaperform solid
carbon filter to remove perchlorate.
N-Acetyl (3,4-Dihydroxybutyl) Cysteine (NABD)
NADB is a metabolite of 1,3 butadiene, which is evident of exposure
to synthetic rubber such as tires. 1,3 butadiene is a known
carcinogen and has been linked to increased risk of cardiovascular
disease. Individuals that come into contact with rubber, such as car
tires, could absorb 1,3 butadiene through the skin.
N-Acetyl (2,Hydroxypropl) Cysteine (NAHP)
NAHP is a metabolite of propylene oxide which is used in the
production of plastics and as a fumigant. It is also used in the
preparation of lubricants, surfactants, and oil demulsifiers and as
a food additive, an herbicide, a microbicide, an insecticide, a
fungicide, and a miticide. Propylene oxide is a probable human
carcinogen.
N-Acetyl (Propyl) Cysteine (NAPR)
NAPR is a metabolite of 1-bromopropane. Chronic exposure can lead to
decreased cognitive function and impairment of the central nervous
system. Acute exposure can lead to headaches.
2-Hydroxyethyl Mercapturic Acid (HEMA)
HEMA is a metabolite of ethylene oxide, which is used in the
production of agrochemicals, detergents, pharmaceuticals, and
personal care products. Chronic exposure to ethylene oxide has been
determined to be mutagenic to humans. HEMA is also a metabolite of
vinyl chloride and halopropane, which are used in many commercial
chemical processes such as foam glueing, dry cleaning, and in the
production of solvents. Supplementation with glutathione should
assist in the detoxification process of these chemicals.
N-Acetyl (2-Cyanoethyl) Cysteine (NACE)
NACE is a metabolite of acrylonitrile, which is used in the
production of acrylic fibers, resins, and rubber. Acrylonitrile is
metabolized by the cytochrome P450s and then conjugated to
glutathione. Supplementation with glutathione should assist in the
detoxification of acrylonitrile.
There are several common considerations for positive findings in the
GPL-TOX panel. If you or a patient has had a GPL-TOX profile and/or
a Glyphosate test run and found moderate-high levels of any
compounds, there are things you can do to help your body eliminate
the toxins and to prevent future exposures. The first steps to
reducing the amount of toxins presently in the body are to switch to
eating only organic food and drinking water that has common toxins,
including pesticides filtered out. Most conventional food crops are
exposed to larger and larger doses of pesticides and herbicides, and
by switching to organic you will prevent exposure to hundreds of
these toxicants. Many of these chemicals have also contaminated our
water supplies. Installing a high-quality reverse osmosis water
filtration system or solid carbon filter such as Multipure in the
home that eliminates them is important to do and there are several
options available. More information will be made available on the
chapter on Water Pollution Solutions.
The next step to avoiding future exposures is to change the products
you use on a daily basis – from food and beverage containers to
beauty and cleaning products. Instead of using plastic water bottles
and food containers, switch to glass or metal. Never microwave food
in plastic or styrofoam containers and do not drink hot beverages
from plastic or styrofoam cups. Make sure your shampoo, soaps,
lotions, and other beauty products are free of phthalates. Use
cleaning products made from natural green ingredients or make your
own at home.
To eliminate toxins from the body, we highly recommend exercise and
the use of saunas, especially infrared sauna therapy to rid many
chemicals through sweat. Infrared sauna is superior to conventional
sauna because it reaches deeper into the body, increasing the
circulation in the blood vessels, and causing the body to start to
releasing many of the chemicals stored in body fat.
There are two supplements that are particularly useful in helping
the body detoxify. The first is glutathione, or its precursor
N-acetyl cysteine. Glutathione is one of the most common molecules
used by the body to eliminate toxic chemicals. If you are constantly
exposed to toxicants your stores of glutathione could be depleted.
The second supplement is vitamin B3 (niacin). Some may not enjoy the
flushing that can happen when taking niacin, however, this flushing
is from the blood vessels dilating, which is useful in the
detoxification process. If sensitive to the flushing, start with the
lowest recommended dose and work up from there.
Heavy Metals And Behavioral Disorders In Children
Behavioral disorders: A pandemic disabling our children
It is normal for children to be energetic and occasionally
distracted, upset, or argumentative. However, when these behaviors
become disruptive and cause harm to the child or others, a diagnosis
of a behavioral disorder may be made. Recent research indicates that
one in six children in the United States is afflicted with
developmental and behavioral disorders, including
attention-deficit/hyperactivity disorder (ADHD), oppositional
defiant disorder, autism spectrum disorder (ASD), anxiety disorder,
learning disorders, and conduct disorders.
According to neurology experts Philippe Grandjean and Philip
Landrigan in a 2014 report in The Lancet Neurology, “a silent
pandemic of neurodevelopmental toxicity” is disabling children
around the world and contributing to the meteoric rise of ADHD, ASD,
and other behavioral disorders. (2) What is responsible for the
rapidly rising rates of behavioral disorders in children? Research
indicates that heavy metal exposure promotes neurodevelopmental
toxicity and may be one of the underlying causes of childhood
behavioral disorders.
Mercury
Childhood exposure to mercury occurs primarily through the
consumption of seafood, vaccines containing thimerosal, and dental
amalgams. Mercury is a potent neurotoxin that directly passes
through the blood–brain barrier and accumulates in brain tissue and
the spinal cord, disrupting neurological function. Children are
especially susceptible to the harmful effects of mercury, and a
growing body of research indicates that mercury exposure is
associated with an increased risk of behavioral disorders.
Prenatal mercury exposure, measured through samples of cord blood,
is associated with ADHD symptoms in children.
Postnatal mercury exposure from thimerosal in vaccines has been
linked to ASD, ADD, ADHD, and tic disorder.
A systematic review of 44 studies concluded that mercury levels were
significantly higher in the whole blood, red blood cells, and brains
of autistic subjects compared to controls.
Mercury content in ambient air is linked to an increased prevalence
of autism in children.
Even low levels of mercury are harmful to the developing brain and
have been associated with learning disabilities.
Heavy metals may play a role in your child’s behavioral disorder.
Learn how to reduce your exposure.
Lead
Lead is a pervasive environmental toxin that adversely affects the
developing nervous system in children. Children may be exposed to
lead through paint chips, dust, and water pipes in homes built prior
to 1978, as well as dirt, drinking water, and air pollution.
In animal studies, prenatal exposure to lead has been found to alter
synapses in the brain, impairing neurotransmission and learning
behaviors.
Children who grew up near the location of a former lead refinery
were found to have a higher risk of ADHD.
Even very low levels of lead have adverse effects on the brain and
behavior in children. Blood lead levels less than 1.8µg/dL, well
below the CDC’s recommended threshold of 5µg of lead per dL of
blood, are associated with an increased risk of ADHD. This suggests
that there is no safe limit for lead exposure in children.
Manganese
Manganese is a heavy metal that is required by the body in small
amounts to create antioxidant enzymes, for the metabolism of
carbohydrates and amino acids, and to promote bone development and
wound healing. It can be found in foods such as green leafy
vegetables, tea, and legumes. However, manganese toxicity can occur
when manganese dust from sources such as chemical manufacturing and
welding is inhaled or when high levels of manganese are present in
drinking water.
Manganese exposure has been linked to ADHD.
Children exposed to high levels of manganese through drinking water
have been found to experience diminished intellectual function and
behavioral problems.
Aluminum
Aluminum is a pervasive heavy metal used as an adjuvant in vaccines,
as a food additive, and in metal cookware, beverage cans, antacids,
and antiperspirants. Research has found high levels of aluminum in
the brain tissue of deceased individuals with autism; the aluminum
was most concentrated in immune cells of the brain, suggesting that
aluminum elicits a neuroimmune response. A significant correlation
also exists between the amounts of aluminum adjuvant administered to
children in vaccines and the prevalence of autism spectrum disorder,
further supporting the theory that aluminum adversely impacts the
developing brain.
Arsenic
Arsenic has become a common contaminant in soil and groundwater due
to its prevalence as a byproduct of industrial manufacturing
processes. Arsenic is also present at high levels in conventionally
raised poultry, which is fed arsenic-containing drugs, and in rice
from India and areas outside of California. Urine arsenic levels
have been associated with decreased IQ in children.
How heavy metals harm the brain
Heavy metals pass through the blood–brain barrier and accumulate in
brain tissue. Once in the brain, they harm neurological function
through several mechanisms.
Heavy metals displace essential minerals such as zinc and iron that
are required for neurotransmitter production.
Heavy metals induce oxidative stress, which reduces neuronal
plasticity and impairs learning and behavior.
Aluminum accumulates in immune cells of the brain. This may provoke
an inflammatory immune response that ultimately affects neurological
function and behavior.
Heavy metal testing
Heavy metal testing is a controversial topic because each of the
currently available methods of testing—hair, urine, and blood—has
some drawbacks.
Hair testing. Hair testing has become a popular method for assessing
heavy metal status. However, using hair testing alone, we cannot
know for certain whether a high level of a metal in the hair
reflects a significant body burden of that metal or indicates that
the patient is efficiently eliminating the metal through the hair
and thus has a low level of it in the body.
Urine testing. Urine heavy metal provocation tests, which use a
chelating agent such as DMSA to provoke a release of heavy metals
into the circulation, present problems similar to those with hair
testing; it is possible that a metal may be high in the urine
because the body is efficient at excreting it, or it may reflect a
high body burden of the metal. Another problem is that reference
ranges for provoked urine results have not been developed or
validated.
Blood testing. Blood testing is problematic for assessing heavy
metal status because heavy metals typically circulate in the blood
for only a short time before becoming sequestered in tissues.
While each of these testing methods is faulty when used alone,
combining a couple of techniques may be a more accurate way to
assess heavy metal toxicity. For example, you could do a provoked
and an unprovoked urine test, or a hair test and a provoked urine
test. Combining two tests may paint a more accurate picture of the
body’s total heavy metal burden.
How to avoid heavy metals
Reducing exposure to heavy metals may lower the risk of childhood
developmental disorders. Pregnant women should be conscientious
about heavy metal exposure because heavy metals cross the placenta
and can affect the brain of the developing fetus. Parents with young
children also need to be careful since the brain is especially
sensitive to toxic insults during childhood.
Chelation And Heavy Metal Detoxification
There are a handful of steps you can take to reduce exposure to
heavy metals:
Don’t use aluminum pans for cooking. Choose stainless steel or
enameled cast iron instead.
Choose seafood low in mercury. The Monterey Bay Aquarium’s Seafood
Watch program is a helpful tool for learning which types of seafood
are highest and lowest in mercury. Wild-caught Alaskan salmon,
wild-caught Pacific sardines, and pole-caught albacore tuna are
among the lower-mercury choices; Atlantic cod, halibut, shark, and
swordfish tend to be much higher in mercury.
Choose thimerosal-free vaccines.
Filter your drinking and bathing water. Invest in a high-quality
drinking water filtration system that removes heavy metals.
Choose organic chicken. Conventionally raised chicken is high in
arsenic.
Limit intake of brown rice and white rice from India and areas
outside of California. Rice from these regions tends to be high in
arsenic. White rice from California is lower in arsenic and thus a
safer option. See my article “Arsenic in Rice: How Concerned Should
You Be?” for more information.
Prevent heavy metal pollution from entering your home. If you have
children and work in manufacturing, construction, or another
profession that involves heavy metal exposure, bathe and change
clothes immediately after work to avoid contaminating your home with
heavy metals in dust, dirt, etc.
Strategies for the treatment of heavy metal toxicity in children
Research indicates that detoxification and excretory pathways
responsible for detoxifying heavy metals may be impaired in children
with behavioral disorders. However, by enhancing detoxification
pathways, replenishing essential minerals and vitamins, and
supplementing with probiotics, it may be possible to alleviate heavy
metal toxicity and reduce symptoms in children with behavioral
disorders.
Support the glutathione pathway
The glutathione pathway is a crucial system in the body for
detoxifying mercury and other heavy metals. Glutathione, often
referred to as the “master antioxidant,” binds to heavy metals and
facilitates their removal from the body. Research has found that ASD
patients have lower glutathione levels than controls, a problem that
may promote the retention of heavy metals in the body. Oral and
transdermal glutathione supplementation raises plasma glutathione
levels in the blood of autistic children, an effect that may
facilitate heavy metal detoxification.
Replenish essential minerals and vitamins
When the body is deficient in essential minerals, heavy metals
preferentially bind to sites normally occupied by those minerals.
Replenishing the body with essential minerals can, therefore, help
prevent heavy metal accumulation and increase metal excretion.
Selenium. Selenium, an essential mineral that serves as a cofactor
for the enzyme glutathione peroxidase, may benefit children with
autism.
Zinc. Another essential mineral, zinc, alleviates heavy metal
toxicity by competing with heavy metals for binding sites on cells
and enzymes. Research indicates that zinc replenishment is
beneficial for kids with autism and ADHD. To replenish zinc levels,
I suggest feeding your children zinc-rich foods, such as oysters,
rather than zinc supplements, which may not be safe for children
over the long term.
Iron. Iron competes with heavy metals for intestinal absorption, and
iron sufficiency downregulates transporters that bring heavy metals
into intestinal cells and the systemic circulation. Restoration of
iron levels has been found to relieve ADHD symptoms in children. I
recommend feeding your kids organ meats and shellfish to ensure
optimal iron levels.
Vitamin B. Replenishment of vitamin B6 may also alleviate heavy
metal toxicity. B6 supplementation reduces the accumulation of lead
in body tissues. When combined with magnesium, it has been found to
improve symptoms of ADHD. The top dietary sources of vitamin B6 are
liver and other organ meats, egg yolks, nuts, bananas, and avocados.
The power of probiotics
Several studies indicate that probiotics alleviate heavy metal
toxicity. Research indicates that Lactobacillus rhamnosus and L.
plantarum, commonly found in probiotic supplements and fermented
foods, protect against heavy metal toxicity. These findings also
suggest that a healthy gut microbiome may protect against heavy
metal toxicity.
Chelation therapy: Use with caution
Chelation therapy involves the use of synthetic chelating agents
such as CaNa2 EDTA and DMSA and may be necessary to remove certain
metals like lead. However, there are significant concerns about the
safety and efficacy of chelation. Chelation depletes essential
minerals and has the potential to redistribute heavy metals within
the body. These effects may be especially harmful to children. For
this reason, chelation should only be done under the guidance of a
qualified healthcare professional. Avoidance of heavy metals and the
use of nutritional detoxification strategies such as those mentioned
above may be a gentler and safer method for reducing a child’s heavy
metal burden.
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