These cannot
prevent the decline in testosterone levels, but they can lead to an
elevated rate of transformation of testosterone into
5-alpha-dihydrotestosterone (DHT) and/or to the increased binding
and/or to the decreased clearance of DHT from prostate cells.
Testosterone is converted to DHT by the enzyme 5-alpha-reductase.
Ultimately, it
is DHT’s actions which cause the enlargement of the prostate. DHT
binds to specific receptors on the prostate cells usually referred
to as androgen receptors. It then is transported into the nucleus of
these cells where it attaches to the DNA and ultimately turns on
prostate growth. As will be explored in more detail below, current
research indicates that DHT is a necessary, but not a sufficient
cause in the etiology of BPH.Andorra,
Andorra la Vella
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